Differential Susceptibility to Bronchial Carcinogenesis in Syngeneic Hamsters1
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چکیده
Previous studies of chemical carcinogenesis in the lung of Syrian golden hamsters have utilized outbred (nonsyngeneic) animals. Using the endobronchial sustained release implant technique, which causes focally orig inating cancers in outbred hamsters, we studied the course of bronchial carcinogenesis in two varieties of syngeneic Syrian golden hamsters, the I SI I and the 1,1) strains (BIO 15.16 male x BIO 87.20 female). With either 10% benzo(<i)pyrene or 10% methylcholanthrene sustained release implants the time course of epithelial transition from normal to neoplastic was the same for 1,1) hamsters as previously described for outbred hamsters. Using 10% benzo(a)pyrene sustained release implants the incidence of cancers as a function of time was significantly lower (/' < 0.001) in 1si I hamsters as compared to outbred and FID animals. Of 19 tumors transplanted into syngeneic 1,1) hamsters, 16 have been success fully propagated by serial transplantation. We conclude that (a) 1,1) hamsters are comparable to outbred animals in the response of their bronchial epithelium to endobronchial benzo(a)pyrene and methylcholanthrene, (b) there are significant differ ences in susceptibility to bronchial chemical carcinogenesis among ham ster strains, thereby giving opportunity to study potential genetic control mechanisms during bronchial carcinogenesis, and (c) 1,1) hamsters are suitable for studies of lung cancer biology using tumor transplantation methods.
منابع مشابه
Differential susceptibility to bronchial carcinogenesis in syngeneic hamsters.
Previous studies of chemical carcinogenesis in the lung of Syrian golden hamsters have utilized outbred (nonsyngeneic) animals. Using the endobronchial sustained release implant technique, which causes focally originating cancers in outbred hamsters, we studied the course of bronchial carcinogenesis in two varieties of syngeneic Syrian golden hamsters, the LSH and the F1D strains (BIO 15.16 mal...
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تاریخ انتشار 2006